When Jose "Juicy" Jusino was three years old, his father taught him to play the congas, bongos and timbales. At the age of five, Juicy's father took him to see Tito Puente and his Orchestra, and encouraged the child to play with a group of children who were playing with Tito. Those children turned out to be Bobby Allende, Tito Allende and Marc Quiñones, and the band became known as The Rumberitos All Stars. The group played with Tito Puente at the Corso, Madison Square Garden, Avery Fischer Hall and at many other locations. Tito also gathered the Rumberitos to do a show with Julio Iglesias. When he was seven years old, Juicy performed with the Fania All Stars, which included Johnny Pacheco, Ray Barretto and Hector Lavoe. His first recorded performance came at the age of nine when he played timbales on a song called Saludo Cordial for Jose Mangual's album Para Bailar Y Gozar.

Juicy continued his musical career while in high school, and also taught his brother, Eric, to play percussion. In 1990, he recorded an album with Groupo Fascinacion, which was never released. After recording three albums with Alberto (El Canario), Juicy toured for four years with Alberto and Celia Cruz. After that, he played with Frankie Ruiz, Eddie Palmieri and various other artists. He then landed a gig with La India and recorded two albums with her, which were nominated for Latin Grammy awards. Soon afterward, Jose toured with Nuyorican Soul, featuring Tito Puente, George Benson, Jocelyn Brown, Hilton Ruiz, Dave Valentin, Roy Ayers and La India.

Juicy continues to perform with La India, and other notable artists such as Marc Anthony, Michael Stuart, Domingo Quiñones, Johnny Rivera, Tony Vega, Tito Nieves, Ray Sepulveda, DLG, Frankie Negron, Kevin Ceballo, Huey Dunbar, Wu Tang Clan and Shannon. He also contributed to the live recording of "Celia Cruz and Friends", which won a Grammy for best live performance and best live recording. Juicy is currently working on a solo project and is the proud, new father of a son, Jose Armando Jusino, Jr.

Juicy sites Tito Puente as one of the most important influences in his life and states that he is proud to use LP® instruments because they are "the best" that he has used during his entire career.